Have used this bag for trips - 17" laptop and all imaginable accessories (USB HDDs, power adapters, and on) files, folders, just about my entire desk. Also use for clinics I teach - laptop (and all above) GoPro and cases. All safe, easy to handle (fully stuffed it is heavy), safe and dry. Could use a few more interior pockets. Been trying to buy a different bag, but can't find a reason to, this satisfies all my needs. Haven't figured out how to get my bike into it yet!